Wednesday 22 May 2013

The Immortal Life of Henrietta Lacks - Rebecca Skloot


Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. 

Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.

Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia—a land of wooden slave quarters, faith healings, and voodoo—to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells. 

Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. 

Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance? 
          
Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

Thursday 16 May 2013

Mr. Penumbra's 24-Hour Bookstore - Robin Sloan


The Great Recession has shuffled Clay Jannon out of his life as a San Francisco Web-design drone—and serendipity, sheer curiosity, and the ability to climb a ladder like a monkey has landed him a new gig working the night shift at Mr. Penumbra’s 24-Hour Bookstore. But after just a few days on the job, Clay begins to realize that this store is even more curious than the name suggests. There are only a few customers, but they come in repeatedly and never seem to actually buy anything, instead “checking out” impossibly obscure volumes from strange corners of the store, all according to some elaborate, long-standing arrangement with the gnomic Mr. Penumbra. The store must be a front for something larger, Clay concludes, and soon he’s embarked on a complex analysis of the customers’ behavior and roped his friends into helping to figure out just what’s going on. But once they bring their findings to Mr. Penumbra, it turns out the secrets extend far outside the walls of the bookstore.

With irresistible brio and dazzling intelligence, Robin Sloan has crafted a literary adventure story for the twenty-first century, evoking both the fairy-tale charm of Haruki Murakami and the enthusiastic novel-of-ideas wizardry of Neal Stephenson or a young Umberto Eco, but with a unique and feisty sensibility that’s rare to the world of literary fiction. Mr. Penumbra’s 24-Hour Bookstore is exactly what it sounds like: an establishment you have to enter and will never want to leave, a modern-day cabinet of wonders ready to give a jolt of energy to every curious reader, no matter the time of day.

Tuesday 14 May 2013

Chapter and Verse - Colin Bateman


Writer Ivan Connor is desperate. His publisher has turned down his wonderful new novel, his agent is out of ideas, and the only person to turn up at his latest reading is his mum. He’s deeply jealous of the marketable Francesca Brady, a hugely successful author of fat romantic books for fat romantic people, whose expansive hair and bright red lipstick mock him from posters everywhere he goes. He’s also living at home since his marriage broke up, and he’s just collected the wrong child from school. 

But one night Connor stumbles on a route back to the top, via a beautiful model, two deranged psychopaths, a multi-million pound publishing fraud, true love and utter heartbreak…

Friday 10 May 2013

The Idea Factory: Bell Labs and the Great Age of American Innovation - Jon Gertner



A sweeping, atmospheric history of Bell Labs that highlights its unparalleled role as an incubator of innovation and birthplace of the century's most influential technologies.
Bell Laboratories, which thrived from the 1920s to the 1980s, was the most innovative and productive institution of the twentieth century. Long before America's brightest scientific minds began migrating west to Silicon Valley, they flocked to this sylvan campus in the New Jersey suburbs built and funded by AT&T. At its peak, Bell Labs employed nearly fifteen thousand people, twelve hundred of whom had PhDs. Thirteen would go on to win Nobel prizes. It was a citadel of science and scholarship as well as a hotbed of creative thinking. It was, in effect, a factory of ideas whose workings have remained largely hidden until now.
"New York Times Magazine" writer Jon Gertner unveils the unique magic of Bell Labs through the eyes and actions of its scientists. These ingenious, often eccentric men would become revolutionaries, and sometimes legends, whether for inventing radio astronomy in their spare time (and on the company's dime), riding unicycles through the corridors, or pioneering the principles that propel today's technology. In these pages, we learn how radar came to be, and lasers, transistors, satellites, mobile phones, and much more.
Even more important, Gertner reveals the forces that set off this explosion of creativity. Bell Labs combined the best aspects of the academic and corporate worlds, hiring the brightest and usually the youngest minds, creating a culture and even an architecture that forced employees in different fields to work together, in virtually complete intellectual freedom, with little pressure to create moneymaking innovations. In Gertner's portrait, we come to understand why both researchers and business leaders look to Bell Labs as a model and long to incorporate its magic into their own work.
Written with a novelist's gift for pacing and an ability to convey the thrill of innovation, "The Idea Factory" yields a revelatory take on the business of invention. What are the principles of innovation? How do new technology and new ideas begin? Are some environments more favorable than others? How should they be structured, and how should they be governed? Can strokes of genius be accelerated, replicated, standardized? The history of Bell Labs provides crucial answers that can and should be applied today by anyone who wants to understand where good ideas come from.